Postdoctoral Fellow
Transposition of mitochondrial DNA into the nuclear genomes gives rise to the socalled nuclear pseudogenes of mitochondrial origin (numts). Numts have been recognized in different quantities in more than 50 genomes. This difference is part of the C-value paradox the lack of correlation between genome size and organism complexity. The differences in numt quantities can be related to dissimilar rates of numt gain, numt loss, and numt post-insertion duplication in different genomes. I have previously shown that in primate lineage most numts are the results of duplications rather than of new insertions. I intend to pursue the research of numt evolution in mammals. More information: http://www.duke.edu/~einat/Einat_Hazkani-Covo/About_Me.html
Numt variation in metazoan genomes: gain, loss, duplication and possible function
PI(s): | Einat Hazkani-Covo |
Start Date: | 1-Jun-2006 |
End Date: | 31-May-2009 |
Keywords: | genomics, comparative methods, gene structure and function |
Transposition of mitochondrial DNA into the nuclear genomes gives rise to the socalled nuclear pseudogenes of mitochondrial origin (numts). Numts have been recognized in different quantities in more than 50 genomes. This difference is part of the C-value paradox the lack of correlation between genome size and organism complexity. The differences in numt quantities can be related to dissimilar rates of numt gain, numt loss, and numt post-insertion duplication in different genomes. I have previously shown that in primate lineage most numts are the results of duplications rather than of new insertions. I intend to pursue the research of numt evolution in mammals. More information: http://www.duke.edu/~einat/Einat_Hazkani-Covo/About_Me.html
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Publications- Directed networks reveal genomic barriers and DNA repair bypasses to lateral gene transfer among prokaryotes O. Popa, E. Hazkani-Covo, G. Landan, W. Martin and T. Dagan (2011) Directed networks reveal genomic barriers and DNA repair bypasses to lateral gene transfer among prokaryotes, Genome Research, volume 21, issue 4, pp. 599-609
- Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes Hazkani-Covo, E., R.M. Zeller, W. Martin and H.S. Malik (2010). Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes. PLoS Genetics 6(2): e1000834.
- Linking big: the continuing promise of evolutionary synthesis Sidlauskas, B., G. Ganapathy, E. Hazkani-Covo, K.P. Jenkins, H. Lapp, L.W. McCall, S. Price, R. Scherle, P.A. Spaeth, and D.M. Kidd (2010). Linking big: the continuing promise of evolutionary synthesis. Evolution 64(4): 871-880.
- Mitochondrial insertions into primate nuclear genomes suggest the use of numts as a tool for phylogeny Hazkani-Covo, E. (2009). Mitochondrial insertions into primate nuclear genomes suggest the use of numts as a tool for phylogeny. Molecular Biology and Evolution 26(10): 2175-2179.
- Numt-Mediated Double-Strand Break Repair Mitigates Deletions During Primate Genome Evolution Hazkani-Covo, E. and S. Covo (2008). Numt-Mediated Double-Strand Break Repair Mitigates Deletions During Primate Genome Evolution. Plos Genetics 4(10): e1000237.
- A Comparative Analysis Of Numt Evolution In Human And Chimpanzee Hazkani-Covo, E. and D. Graur (2007). A Comparative Analysis Of Numt Evolution In Human And Chimpanzee. Molecular Biology And Evolution 24(1): 13-18.
- Hazkani-Covo E and Covo S. What evolution can teach us about double strand break repair: comparative genome analysis of numt loci enables detection of double strand break repair events at a molecular level. Society of Molecular Biology and Evolution (SMBE), Halifax, Canada. July 2007.