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Supported Projects > Long-term Sabbatical: 1) distribution of fitness effects of new mutations and 2) the rate of adaptive evolution
Long-term Sabbatical
1) distribution of fitness effects of new mutations and 2) the rate of adaptive evolution
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| PI(s): |
Adam Eyre-Walker (University of Sussex) |
| Start Date: |
1-Oct-2005 |
| End Date: |
30-Sep-2006 |
| Keywords: |
mutation, evolutionary genetics, quantitative genetics, mathematical modeling |
All organisms suffer from genetic mutation. At least some of these are harmful such that they reduce the probability of survival or fertility. But how harmful are these mutations? This is a question which lies at the heart of many problems, from how much genetic variation can be maintained in a population, to the evolution of sex and the genetic basis of human disease. The aim of the project is to develop methods to estimate the proportion of mutations which are strongly, mildly and weakly deleterious, and to apply these methods to a variety of data from humans and fruit flies
Related products
Publications
- Human Triallelic Sites: Evidence for a New Mutational Mechanism? A. Hodgkinson and A. Eyre-Walker (2010). Human Triallelic Sites: Evidence for a New Mutational Mechanism?, Genetics 184(1): 233-241.
- What can we learn about the distribution of fitness effects of new mutations from DNA sequence data? P. D. Keightley and A. Eyre-Walker (2010). What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?, Philosophical Transactions of the Royal Society B: Biological Sciences 365(1544): 1187-1193.
- Cryptic Variation In The Human Mutation Rate Hodgkinson, A., E. Ladoukakis, and A. Eyre-Walker (2009). Cryptic Variation In The Human Mutation Rate. Plos Biology 7(2): 226-232.
- The Effect of Transposable Element Insertions on Gene Expression Evolution in Rodents Vini Pereira, David Enard, Adam Eyre-Walker and I. King Jordan. 2009, The Effect of Transposable Element Insertions on Gene Expression Evolution in Rodents, PLoS ONE 4(2): e4321.
- The Excess Of Small Inverted Repeats In Prokaryotes Ladoukakis, E.D. and A. Eyre-Walker (2008). The Excess Of Small Inverted Repeats In Prokaryotes. Journal Of Molecular Evolution 67(3): 291-300.
- The McDonald-Kreitman test and slightly deleterious mutations Charlesworth, J. and A. Eyre-walker (2008). The McDonald-Kreitman test and slightly deleterious mutations. Mol. Biol. Evol. 25: 1007-1015.
- Synonymous Codon Use in Escherichia coli - Selection for translational accuracy Stoletzki, N. and A. Eyre-Walker (2007). Synonymous Codon Use in Escherichia coli - Selection for translational accuracy. Mol. Biol. Evol. 24: 374-381.
- The other side of the neutral theory, evidence for slightly advantageous back-mutations Charlesworth, J. and A. Eyre-walker (2007). The other side of the neutral theory, evidence for slightly advantageous back-mutations. Proc. Natl. Acad. Sci. 104(43):16992-16997.
- The distribution of fitness effects of new mutations Eyre-Walker, A. and P.D. Keightley (2007). The distribution of fitness effects of new mutations. Nature Reviews Genetics 8: 610-618
- The distribution of fitness effects of new deleterious amino acid mutations in humans Eyre-Walker, A., M. Woolfit, and T. Phelps (2006). The distribution of fitness effects of new deleterious amino acid mutations in humans. Genetics 173: 891-900.
- The rate of adaptive evolution in enteric bacteria Charlesworth, J. and A. Eyre-Walker (2006). The rate of adaptive evolution in enteric bacteria. Mol. Biol. Evol. 23: 1348-1356.
- Size does not matter for mitochondrial DNA Eyre-Walker, A. (2006). Size does not matter for mitochondrial DNA. Science 312(5773): 537-538.
- A New Perspective On Isochore Evolution Duret, L, A. Eyre-Walker, and N. Galtier (2006). A New Perspective On Isochore Evolution. Gene 385: 71-74.
- The Genomic Rate Of Adaptive Evolution Eyre-Walker, A. (2006). The Genomic Rate Of Adaptive Evolution. Trends In Ecology & Evolution 21(10): 569-575.
