Postdoctoral Fellow
hI am undertaking comparative genomic studies of the DNA sequences responsible for regulating gene expression. These regulatory sequences are important sites of evolutionary change, and I am therefore investigating changes in regulatory sequences that have played a significant role in the evolution of new species. I am also working to understand the manner and mechanisms, by which regulatory sequences evolve. The selective pressure on these sequences is to maintain specific levels of expression under certain conditions. Due to this selection, and the mechanism of regulation, these sequences experience a great degree of evolutionary freedom, which presents unique challenges to their study.
Comparative genomic studies of the sequences responsible for the regulation of gene expression
PI(s): | Joshua Granek |
Start Date: | 1-Aug-2005 |
End Date: | 31-Jul-2007 |
Keywords: | comparative methods, genomics, natural selection |
hI am undertaking comparative genomic studies of the DNA sequences responsible for regulating gene expression. These regulatory sequences are important sites of evolutionary change, and I am therefore investigating changes in regulatory sequences that have played a significant role in the evolution of new species. I am also working to understand the manner and mechanisms, by which regulatory sequences evolve. The selective pressure on these sequences is to maintain specific levels of expression under certain conditions. Due to this selection, and the mechanism of regulation, these sequences experience a great degree of evolutionary freedom, which presents unique challenges to their study.